https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.117.188101#fulltext

SUPPLEMENTARY:https://journals.aps.org/prl/supplemental/10.1103/PhysRevLett.117.188101/supplement.pdf

abstract

fail-safe(自动防故障的)
robust self-organization phenomenon
cell migration(迁移) trajectory（轨道）
mechanical cues
push cells into position where they experience the least repulsive forces
mechanically guided progress is properly timed
how : remained elusive(difficult to know)
cell volumes and division times are strongly anticorrelated
somatic cells and precursor of germline are correlated
their experimental findings by a simple models
- model in conjunction with mechanical guidance can account for the fail-safe early embryogenesis of C.elegans.

introduction

C.ELEGANS are protected and eutely.
EUTELY : require egg shell robust and fail-safe, migrate to meaningful spatial positions.
migration is invarient.
explained:machanical model
- cells interact via repulsive protentials(势能)
- it predicted cells to relax towards positions of least repulsion after miosis(有丝分裂)
how do individual cells know
- right now is a good choice for a meaningful and robust mechanically driven arrangement of all cells in the embryo
onset of gastrulation
how individual cells are coupled to the mechanics of the rest fo the embryo

P granules are deposited in cells of P lineage
P granules have benn implicated to sequester(使隐退) NPCs
- why alpha is bigger the cells of other lineage
Maybe linked to a temporal

control timming can inflence division
- and late division result in mechanical difference.
- mechanically driven migration exist.